Four-color fluorescence in-situ hybridization is useful to assist to distinguish early stage acral and cutaneous melanomas from dysplastic junctional or compound nevus

Table 1 Clinicopathological feature of dysplastic nevi and early-stage acral and cutaneous melanomas

Feature	DN(50 cases), n(%)	Melanoma(59cases), n(%)	p^a value
Gender ratio (male:female)	20:30 (0.67:1)	25:34 (0.74:1)	.802
Age, range (mean)	3–70 (36.60)	9–76 (47.73)	< .001*
Site
Acral	31 (62.0)	42 (71.2)	.169
Trunk	9 (18.0)	6 (10.3)
Limb	9 (18.0)	6 (10.2)
Others	1 (2.0)	5 (8.5)
mitotic figures≥1/mm²	1 (2.0)	23 (39.0)	< .001*
Diameter, range (mean, mm)	1–20 (7.30)	2–40 (11.34)	.002*
Stratum corneum pigmentation	17 (34.0)	38 (64.4)	.002*
Moderate to severe lymphocyte infiltration	6 (12.0)	28 (47.5)	< .001*
Moderate to severe cell atypia	6 (12.0)	52 (88.1)	< .001*
Melanocyte growth pattern in the epidermis
Concessive distribution	20 (40.0)	48 (81.4)	< .001*
Pagetoid spread	2 (4.0)	20 (33.9)	< .001*
Nested distribution	33 (66.0)	44 (74.6)	.327
Scattered distribution	37 (74.0)	26 (44.1)	.002*

Abbreviations: DN dysplastic nevus, n number
^ap values from Pearson’s chi-square test, independent t-test. *p < .05, considered statistically significant

ISSN: 1746-1596