Table 1 DNA damage repair genes included in FoundationOne CDx NGS panel
From: High tumor mutation burden is associated with DNA damage repair gene mutation in breast carcinomas
| Pathways | NER | MMR | FA | HR | Checkpoint | Others |
|---|---|---|---|---|---|---|
| Genes | ERCC2 | MLH1 | BRCA2 | BRCA1 | ATM | POLE |
| ERCC3 | MSH2 | BRIP1 | MRE11A | ATR | MUTYH | |
| ERCC4 | MSH6 | FANCA | NBN | CHEK1 | PARP1 | |
| ERCC5 | PMS1 | FANCC | RAD50 | CHEK2 | RECQL4 | |
| PMS2 | PALB2 | RAD51 | MDC1 | |||
| RAD51C | RAD51B | |||||
| BLM | RAD51D | |||||
| RAD52 | ||||||
| RAD54L |