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Table 3 The association between cytoplasmic and nuclear TWIST1 expressions and clinicopathological parameters of colorectal cancer (CRC) samples (H-score) (P value; Pearson’s χ2 test)

From: Expressions of TWIST1 and CD105 markers in colorectal cancer patients and their association with metastatic potential and prognosis

Patients and tumor characteristics Total samples N (%) H-score (cut off = 149) N (%) Cytoplasmic TWIST1 expression P-value H-score (cut off = 172) N (%) Nuclear TWIST1 expression P-value
Low (≤ 149) High (>  149) Low (≤ 172) High (>  172)
Number of CRC samples 223 113 (50.7) 110 (49.3) 87 (39.0) 136 (61.0)
Mean age, years (Range) 59 (20–91)    0.159    0.262
  ≤ Mean age 110 (49.3) 61 (54.0) 49 (44.5)   47 (54.0) 63 (46.3)  
  > Mean age 113 (50.7) 52 (46.0) 61 (55.5)   40 (46.0) 73 (53.7)  
Gender     0.095    0.129
 Male 114 (51.1) 64 (56.6) 50 (45.5)   50 (57.5) 64 (47.1)  
 Female 109 (48.9) 49 (43.4) 60 (54.5)   37 (42.5) 72 (52.9)  
 (Male/Female) 1.04 1.30 0.83   1.35 0.88  
Mean tumor size (cm) 5    0.389    0.522
  ≤ Mean 156 (70.0) 82 (72.6) 74 (67.3)   63 (72.4) 93 (68.4)  
  > Mean 67 (30.0) 31 (27.4) 36 (32.7)   24 (27.6) 43 (31.6)  
Tumor differentiation     0.549    0.405
 Well 103 (46.2) 53 (46.9) 50 (45.5)   45 (51.7) 58 (42.6)  
 Moderate 104 (46.6) 50 (44.2) 54 (49.1)   36 (41.4) 68 (50.0)  
 Poor 16 (7.2) 10 (8.8) 6 (5.5)   6 (6.9) 10 (7.4)  
TNM stage     0.932    0.831
 I 40 (17.9) 19 (16.8) 21 (19.1)   16 (18.4) 24 (17.6)  
 II 98 (43.9) 52 (46.0) 46 (41.8)   40 (46.0) 58 (42.6)  
 III 79 (35.4) 39 (34.5) 40 (36.4)   28 (32.2) 51 (37.5)  
 IV 6 (2.7) 3 (2.7) 3 (2.7)   3 (3.4) 3 (2.2)  
Vascular invasion (VI)     0.783    0.445
 Present 36 (16.1) 19 (16.8) 17 (15.5)   12 (13.8) 24 (17.6)  
 Absent 187 (83.9) 94 (83.2) 93 (84.5)   75 (86.2) 112 (82.4)  
Lymph node invasion (LNI)     0.878    0.571
 Involved 82 (36.8) 41 (36.3) 41 (37.3)   30 (34.5) 52 (38.2)  
 None 141 (63.2) 72 (63.7) 69 (62.7)   57 (65.5) 84 (61.8)  
Neural invasion (NI)     0.697    0.653
 Involved 47 (21.1) 25 (22.1) 22 (20.0)   17 (19.5) 30 (22.1)  
 None 176 (78.9) 88 (77.9) 88 (80.0)   70 (80.5) 106 (77.9)  
Distant metastasis     0.234    0.045
 Present 37 (16.6) 15 (13.3) 22 (20.0)   8 (9.2) 29 (21.3)  
 Absent 100 (44.8) 52 (46.0) 48 (43.6)   40 (46.0) 60 (44.1)  
Not identified 86 (38.6) 46 (40.7) 40 (36.4)   39 (44.8) 47 (34.6)  
Tumor recurrence     0.568    0.149
 Yes 42 (18.8) 19 (16.8) 23 (20.9)   11 (12.7) 31 (22.8)  
 No 95 (42.6) 48 (42.5) 47 (42.7)   37 (42.5) 58 (42.6)  
Not identified 86 (38.6) 46 (40.7) 40 (36.4)   39 (44.8) 47 (34.6)  
  1. H-score indicates histological score
  2. Values in bold are statistically significant
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Diagnostic Pathology

ISSN: 1746-1596

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