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Table 4 The association between cytoplasmic and endothelial CD105 expressions and clinicopathological parameters of colorectal cancer (CRC) samples (H-score) (P value; Pearson’s χ2 test)

From: Expressions of TWIST1 and CD105 markers in colorectal cancer patients and their association with metastatic potential and prognosis

Patients and tumor characteristics Total samples N (%) H-score (cut off = 26) N (%) Cytoplasmic CD105 expression P-value H-score (cut off = 284) N (%) Endothelial CD105 expression P-value
Low (≤ 26) High (>  26) Low (≤ 284) High (>  284)
Number of CRC samples 208 121 (58.2) 87 (41.8) 34 (16.3) 174 (83.7)
Mean age, years (Range) 59 (25–88)    0.796    0.358
  ≤ Mean age 105 (50.5) 62 (51.2) 43 (49.4)   20 (58.9) 85 (48.9)  
  > Mean age 103 (49.5) 59 (48.8) 44 (50.6)   14 (41.1) 89 (51.1)  
Gender     0.872    0.305
 Male 111 (53.4) 64 (52.9) 47 (54.0)   15 (44.1) 96 (55.2)  
 Female 97 (46.6) 57 (47.1) 40 (46.0)   19 (55.9) 78 (44.8)  
 (Male/Female) 1.14 1.12 1.17   0.78 1.23  
Mean tumor size (cm) 5    0.472    0.693
  ≤ Mean 145 (69.7) 82 (67.8) 63 (72.4)   23 (67.7) 122 (70.1)  
  > Mean 63 (30.3) 39 (32.2) 24 (27.6)   11 (32.3) 52 (29.9)  
Tumor differentiation     0.605    0.450
 Well 89 (42.8) 55 (45.5) 34 (39.1)   12 (35.2) 77 (44.3)  
 Moderate 107 (51.4) 60 (49.6) 47 (54.0)   21 (61.7) 86 (49.4)  
 Poor 12 (5.8) 6 (5.0) 6 (6.9)   1 (3.1) 11 (6.3)  
TNM stage     0.050    0.631
 I 29 (13.9) 14 (11.6) 15 (17.2)   7 (20.5) 22 (12.6)  
 П 92 (44.2) 62 (51.2) 30 (34.5)   13 (38.2) 79 (45.4)  
 III 80 (38.5) 43 (35.5) 37 (42.5)   13 (38.2) 67 (38.5)  
 IV 7 (3.4) 2 (1.7) 5 (5.7)   1 (3.1) 6 (3.4)  
Vascular invasion (VI)     0.587    0.711
 Present 37 (17.8) 23 (19.0) 14 (16.1)   6 (17.6) 31 (17.8)  
 Absent 171 (82.2) 98 (81.0) 73 (83.9)   28 (82.4) 143 (82.2)  
Lymph node invasion (LNI)     0.713    0.978
 Involved 83 (39.9) 47 (38.8) 36 (41.4)   14 (41.1) 69 (39.7)  
 None 125 (60.1) 74 (61.2) 51 (58.6)   20 (58.9) 105 (60.3)  
Neural invasion (NI)     0.371    0.241
 Involved 57 (27.4) 36 (29.8) 21 (24.1)   12 (35.2) 45 (25.9)  
 None 151 (72.6) 85 (70.2) 66 (75.9)   22 (64.8) 129 (74.1)  
Distant metastasis     0.662    0.438
 Present 30 (14.5) 20 (16.5) 10 (11.5)   3 (8.9) 27 (15.5)  
 Absent 91 (43.7) 57 (47.1) 34 (39.1)   16 (47.0) 75 (43.1)  
Not identified 87 (41.8) 44 (36.4) 43 (49.4)   15 (44.1) 72 (41.4)  
Tumor recurrence     0.707    0.530
 Yes 36 (17.3) 22 (18.1) 14 (16.1)   4 (11.8) 32 (18.4)  
 No 85 (40.9) 55 (45.5) 30 (34.5)   14 (41.2) 71 (40.8)  
Not identified 87 (41.8) 44 (36.4) 43 (49.4)   16 (47.0) 71 (40.8)  
  1. H-score indicates histological score
  2. Values in bold are statistically significant
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Diagnostic Pathology

ISSN: 1746-1596

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