Expressions of TWIST1 and CD105 markers in colorectal cancer patients and their association with metastatic potential and prognosis

Table 5 Univariate and multivariate Cox regression analyses of potential prognostic factor for disease-specific survival (DSS) in patients with colorectal cancer

Covariate	Univariate analysis		Multivariate analysis
Covariate	HR (95% CI)	P-value	HR (95% CI)	P-value
Nuclear TWIST1 expression High versus Low	2.04 (1.0–4.1)	0.048	1.6 (0.8–3.4)	0.158
Tumor size (cm)	1.8 (1.0–3.5)	0.040	1.5 (0.8–2.8)	0.168
Tumor differentiation		< 0.001		0.003
Moderate versus well	2.7 (1.3–5.5)	0.004	2.4 (1.2–4.9)	0.013
Poor versus well	6.1 (2.4–15.7)	< 0.001	5.0 (1.9–13.0)	0.001
Vascular invasion (VI)	0.4 (0.2–0.9)	0.030	–	–
Neural invasion (NI)	0.3 (0.1–0.5)	< 0.001	–	–
Lymph node invasion (LNI)	0.5 (0.2–0.9)	0.033	–	–
Distant metastasis	0.1 (0.0–0.2)	< 0.001	–	–
Tumor recurrence	0.1)0.05–0.20)	< 0.001	–	–

H-score indicates histological score
Values in bold are statistically significant
The variables with P value less than 0.05 were included in multivariable analyses
HR hazard ratio, CI confidence interval

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