Expressions of TWIST1 and CD105 markers in colorectal cancer patients and their association with metastatic potential and prognosis

Table 6 Univariate and multivariate Cox regression analyses of potential prognostic factor for progression- free survival (PFS) in patients with colorectal cancer

Covariate	Univariate analysis		Multivariate analysis
Covariate	HR (95% CI)	*P-value*	HR (95% CI)	*P-value*
Nuclear TWIST1 expression High versus Low	1.9 (1.0–3.6)	0.049	1.62 (0.84–3.13)	0.149
Tumor differentiation		< 0.001		< 0.001
Moderate versus well	2.5 (1.3–4.7)	0.005	2.2 (1.1–4.3)	0.013
Poor versus well	6.3 (2.6–15.0)	< 0.001	5.4 (2.2–13.3)	< 0.001
Neural invasion (NI)	0.3 (0.1–0.5)	< 0.001	–	–
Lymph node invasion (LNI)	0.5 (0.3–0.9)	0.038	–	–
Distant metastasis	0.1 (0.0–0.3)	< 0.001	–	–
Tumor recurrence	0.1 (0.0–0.2)	< 0.001	–	–

H-score indicates histological score
Values in bold are statistically significant
The variables with P value less than 0.05 were included in multivariable analyses
hazard ratio, CI confidence interval

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